Antigenic and virological properties of an H3N2 variant that continues to dominate the 2021-22 Northern Hemisphere influenza season2021-22 북반구 인플루엔자 시즌을 계속 지배하는 H3N2 변이체의 항원 및 바이러스 특성Article Published on 2022-05-312022-09-11 Journal: Cell Reports [Category] 변종, [키워드] Alter antibodies antibody antigenic antigenic mismatch binding COVID-19 pandemic CP: Microbiology elicited glycosylation site H3N2 H3N2 strain hemagglutinin Hemisphere human airway cells human cell human cells Influenza influenza vaccine Influenza virus influenza virus. influenza viruses maintain Microbiology neutralize population immunity replicate sialic acid Substitution These data these viruses Vaccine vaccine strain variant Virological virus [DOI] 10.1016/j.celrep.2022.110897 PMC 바로가기 [Article Type] Article
Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge마우스-적응 된 SARS-COV-2는 치명적인 SARS-COV 도전으로부터 동물을 보호한다Research Article Published on 2021-11-042022-08-13 Journal: PLoS Biology [Category] Biochemistry, MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome coronavirus antigenicity CMA3p20 coronavirus coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 CoV COVID-19 Critical cross-protection disease Economy element generate Heterologous heterologous challenge highlight human airway cell human airway cells human infection human SARS-CoV-2 strains Immune cell infiltration Immunity impair in vivo incorporation lack lung maintain mechanism Mouse models mouse-adapted SARS-CoV-2 mouse-adapted SARS-CoV-2 strains mouse-adapted strain mouse-adapted strain of SARS-CoV-2 Mutation natural infection offer overcome pandemic PROTECT public health Replication Research respiratory reverse genetic system robust SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants SARS-CoV-2–infected mice severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Strains Vaccine variants variants of concern Viral viral replication [DOI] 10.1371/journal.pbio.3001284 PMC 바로가기 [Article Type] Research Article
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cellsResearch Article Published on 2020-07-232022-10-30 Journal: Life Science Alliance [Category] COVID-19, SARS, [키워드] activated Activation acute infection antiviral activity approach Calu-3 cathepsin Cell cells cleaved COVID-19 E64d equimolar furin furin inhibitor host cell proteases human airway cell human airway cells human airway epithelial inhibited inhibition knockdown not affect produced protease proteolytic activation provide respiratory tract S1/S2 site S2′ site SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 S serine protease inhibitor severe disease Spike protein Spread Surface glycoprotein targets the S protein therapeutic potential TMPRSS2 TMPRSS2 expression TMPRSS2 inhibitor transmembrane serine protease Treatment virus entry virus replication [DOI] 10.26508/lsa.202000786 PMC 바로가기 [Article Type] Research Article
Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virusArticle Published on 2008-02-262023-06-14 Journal: Proceedings of the National Academy of Sciences of [Category] Fulltext, 신종인플루엔자, [키워드] human airway cells mice Pathogenesis [DOI] 10.1073/pnas.0711815105 PMC 바로가기